解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Unstable angina (UA) is one of the most dangerous types of coronary heart disease and has high mortality and morbidity rates worldwide. However, the diagnostic accuracy for UA is unsatisfactory in clinical practice. In this study, we investigated the application of plasma metabolomics in discovering potential biomarke...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb70216b
更新日期:2013-12-01 00:00:00
abstract::All trans-retinoic acid (ATRA) is widely used to direct the differentiation of cultured stem cells. When exposed to the pluripotent human embryonal carcinoma (EC) stem cell line, TERA2.cl.SP12, ATRA induces ectoderm differentiation and the formation of neuronal cell types. We report in this study that novel polyene ch...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb70273a
更新日期:2013-12-01 00:00:00
abstract::Dynamic physical interactions between proteins underpin all key cellular processes and are a highly attractive area for the development of research tools and medicines. Protein-protein interactions frequently involve α-helical structures, but peptides matching the sequences of these structures usually do not fold corr...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb70246d
更新日期:2013-11-01 00:00:00
abstract::Chronic heart failure (CHF), as a progressive clinical syndrome, is characterized by failure of enough blood supply from the heart to meet the body's metabolic demands, and there is intense interest in identifying novel biomarkers that could make contributions to the diagnosis of CHF. Metabolomics, compared with curre...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb70227h
更新日期:2013-11-01 00:00:00
abstract::Diabetic nephropathy (DN) is a serious metabolic disease, and comprehensive understanding of its complex mechanism will help in preventing the onset and progression of DN. To reveal the systemic metabolic changes associated with renal injury, we performed 1H NMR-based metabonomic and multivariate analyses to analyze s...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb70212j
更新日期:2013-11-01 00:00:00
abstract::The main objectives of this work were to characterise a range of purified recombinant sterol 3β-glucosyltransferases and show that rational sampling of the diversity that exists within sterol 3β-glucosyltransferase sequence space can result in a range of enzyme selectivities. In our study the catalytically active doma...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb70303g
更新日期:2013-11-01 00:00:00
abstract::The knowledge available about the application and generation of induced pluripotent stem cells (iPSC) has grown since their discovery, and new techniques to enhance the reprogramming process have been described. Among the new approaches to induce iPSC that have gained great attention is the use of small molecules for ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb70159j
更新日期:2013-11-01 00:00:00
abstract::As one of the most important trace elements within an organism, zinc has been shown to be involved in numerous biological processes and closely implicated in various diseases. The zinc ion is important for proteins to perform their functional roles. To provide in-depth functional annotation of zinc-binding proteins, a...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb70100j
更新日期:2013-09-01 00:00:00
abstract::Here we present a novel statistical methodology that allows us to analyze gene expression data that have been collected from a number of different cases or conditions in a unified framework. Using a Bayesian nonparametric framework we develop a hierarchical model wherein genes can maintain a shared set of interactions...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb25497f
更新日期:2013-07-01 00:00:00
abstract::It is now widely accepted that microRNAs (miRNAs or miRs) along with transcription factors (TFs) weave a complex inter-regulatory network within the cell that is responsible for the combinatorial regulation of gene expression. Recently we have shown that miRNAs and TFs that form network clusters are also associated wi...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb25518b
更新日期:2013-06-01 00:00:00
abstract::In the last few decades a negative association between the level of milk production and fertility has been observed. Currently, the most utilized method of measuring male fertility employed by the livestock industry is related to the Non-Return Rate (NRR). Through differential proteome analysis, this study evaluated c...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb25494a
更新日期:2013-06-01 00:00:00
abstract::The molecular segmentation clock is a complex regulatory network that governs the periodic somite segmentation in vertebrate embryos. Underlying the rhythm of the segmentation clock is a single-cell level pace-making circuit, where inevitable molecular noise and time delay impose normal operating constraints to the pa...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb70046a
更新日期:2013-06-01 00:00:00
abstract::The epithelial to mesenchymal transition (EMT) is a cellular program associated with the organ morphogenesis but also with the disease progression. EMT in the cancer field fuels neoplastic progression promoting the resistance to cell death, the resistance to chemotherapy and the acquisition of stem cell properties. Co...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25401h
更新日期:2013-06-01 00:00:00
abstract::A genome-wide screen of a yeast non-essential gene-deletion library was used to identify sick phenotypes due to oxygen deprivation. The screen provided a manageable list of 384 potentially novel as well as known oxygen responding (anoxia-survival) genes. The gene-deletion mutants were further assayed for sensitivity t...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb25516f
更新日期:2013-06-01 00:00:00
abstract::Are protein functions continuous or discretized? Proteomics investigations are starting to address this non-trivial awesome question focusing upon determining the nature of biological molecular relationships. In the following editorial we present a number of experimental studies published in this themed Proteomics Iss...
journal_title:Molecular bioSystems
pub_type: 社论
doi:10.1039/c3mb90013d
更新日期:2013-06-01 00:00:00
abstract::Cystic fibrosis (CF) is an autosomal recessive disorder associated with mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene and defective chloride transport across the epithelial cell membranes. Abnormal epithelial ion transport is the primary cause of persistent airway infections and chro...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb25594h
更新日期:2013-06-01 00:00:00
abstract::Oxygen dependent modulation of red blood cell metabolism is a long investigated issue. However, the recent introduction of novel mass spectrometry-based approaches lends itself to implement our understanding of the effects of red blood cell prolonged exposure to anaerobiosis. Indeed, most of the studies conducted so f...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb25575a
更新日期:2013-06-01 00:00:00
abstract::This paper describes a sensitive, non-destructive displacement assay, using a fluorescent peptide indicator, for real-time monitoring of the interactions between RNA and RNA binding proteins (RBPs). The developed fluorescent peptide indicators, each containing a mid-sequence fluorophore unit, allowed sensing of target...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25470k
更新日期:2013-05-01 00:00:00
abstract::Synthetic studies of lipid A and LPS partial structures have been performed to investigate the relationship between structures and functions of LPS. Recent studies have suggested several pathological implications of LPS from parasitic bacteria due to its influence on the host immune responses. To address this issue, w...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb25477a
更新日期:2013-05-01 00:00:00
abstract::In vivo analysis is of paramount importance in monitoring physiological processes that take place in living organisms. Mass spectrometry, an analytical technique with high speed, sensitivity and specificity, is indispensable in biochemical studies nowadays. However, traditional mass spectrometric techniques are of lim...
journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
doi:10.1039/c2mb25428j
更新日期:2013-05-01 00:00:00
abstract::G protein-coupled receptors (GPCRs) are key signaling proteins that regulate how cells interact with their environment. Traditional signaling cascades involving GPCRs have been well described and are well established and very important clinical targets. With the development of more recent technologies, hints about the...
journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
doi:10.1039/c2mb25429h
更新日期:2013-04-05 00:00:00
abstract::Predicting protein subcellular localization is a challenging problem, particularly when query proteins have multi-label features meaning that they may simultaneously exist at, or move between, two or more different subcellular location sites. Most of the existing methods can only be used to deal with the single-label ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb25466f
更新日期:2013-04-05 00:00:00
abstract::In the post-genome era, one of the most important and challenging tasks is to identify the subcellular localizations of protein complexes, and further elucidate their functions in human health with applications to understand disease mechanisms, diagnosis and therapy. Although various experimental approaches have been ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb25451h
更新日期:2013-04-05 00:00:00
abstract::The heterogeneity of genetic alterations in human cancer genomes presents a major challenge to advancing our understanding of cancer mechanisms and identifying cancer driver genes. To tackle this heterogeneity problem, many approaches have been proposed to investigate genetic alterations and predict driver genes at th...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25528f
更新日期:2013-03-01 00:00:00
abstract::Enediyne natural product biosynthesis is characterized by a convergence of multiple pathways, generating unique peripheral moieties that are appended onto the distinctive enediyne core. Kedarcidin (KED) possesses two unique peripheral moieties, a (R)-2-aza-3-chloro-β-tyrosine and an iso-propoxy-bearing 2-naphthonate m...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c3mb25523a
更新日期:2013-03-01 00:00:00
abstract::As a potential target for the treatment of schizophrenia, the dual cAMP/cGMP hydrolyzing enzyme PDE10A has attracted a significant amount of attention. In the present work, the inhibition mechanism of 116 structurally diverse quinoline derivatives as PDE10A inhibitors was explored by 3D-QSAR, molecular docking and mol...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25501d
更新日期:2013-03-01 00:00:00
abstract::4-Hydroxyderricin is a heat labile bioactive chalcone isolated from the plant Angelica keiskei. It received attention due to its antibiotic potency against several strains of bacteria including pathogens such as Staphylococcus aureus. Despite these promising pharmacological properties, the exact mode of action or the ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25446h
更新日期:2013-03-01 00:00:00
abstract::To faithfully execute diverse biological programs all cells need to access and distribute their genomes in a highly organized way. In the nucleus of eukaryotic cells DNA is packed with histone proteins into chromatin. The originating nucleo-protein complex is the regulatory platform for all genetic processes. Of these...
journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
doi:10.1039/c2mb25328c
更新日期:2013-02-02 00:00:00
abstract::Candida glabrata has been recognized as an efficient industrial microorganism for the production of pyruvate, the most widely used α-oxocarboxylic acid in the areas of agrochemicals, drugs, and chemicals. To gain a comprehensive understanding of its physiology and cellular metabolism, the genome-scale metabolic model ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25311a
更新日期:2013-02-02 00:00:00
abstract::Despite many prior studies on microbial response to oxidative stress, our understanding of microbial tolerance against oxidative stress is currently limited to aerobic conditions, and few engineering strategies have been devised to resolve toxicity issues of oxidative stress under anaerobic conditions. Since biologica...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25259g
更新日期:2013-02-02 00:00:00
abstract::Regulatory networks are able to process complex signals and respond appropriately to the cellular context. Thus, an increasing effort by systems biology researchers is being focused on understanding which interactions are responsible for a given functional response. When translated into specific mathematical models, h...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25243k
更新日期:2013-02-02 00:00:00
abstract::Induced reprogramming of somatic cells has had a great impact on stem cell research, and the reprogramming technologies have evolved from four transgenic factors (Oct4, Sox2, Klf4, and c-Myc; OSKM) to just a few microRNAs (mainly miR-290/302 seed family). Despite these advances, the molecular events occurring during v...
journal_title:Molecular bioSystems
pub_type: 杂志文章,评审
doi:10.1039/c2mb25088h
更新日期:2013-01-27 00:00:00
abstract::Understanding the molecular mechanism that underlies the differentiation of neural stem cells (NSCs) is vital to develop regenerative medicines for neurological disorders. In our previous work, Rho-GDI-γ was found to be able to prompt neuronal differentiation when it was down regulated. However, it is unclear how Rho-...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25147g
更新日期:2012-11-01 00:00:00
abstract::α-Alkylidene-γ-butyrolactones are quite common in nature and exhibit a broad spectrum of biological activities. We therefore synthesized a small library of xanthatine inspired α-alkylidene-γ-butyrolactones to screen non-pathogenic and uropathogenic E. coli strains by activity based protein profiling (ABPP). The identi...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25313e
更新日期:2012-11-01 00:00:00
abstract::To understand the regulatory dynamics of transcription factors (TFs) and their interplay with other cellular components we have integrated transcriptional, protein-protein and the allosteric or equivalent interactions which mediate the physiological activity of TFs in Escherichia coli. To study this integrated network...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25279a
更新日期:2012-11-01 00:00:00
abstract::The glutamate γ-carboxylation plays a pivotal part in a number of important human diseases. However, traditional protein γ-carboxylation site detection by experimental approaches are often laborious and time-consuming. In this study, we initiated an attempt for the computational prediction of protein γ-carboxylation s...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25185j
更新日期:2012-11-01 00:00:00
abstract::A recent model proposing that a barrier is raised against tumor evolution in pre-cancer tissues is investigated. For that we quantify expression alterations in genome maintenance pathways: DNA damage response, death pathways and cell cycle and also differentially expressed genes in transcriptomes of pre-cancerous and ...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25242b
更新日期:2012-11-01 00:00:00
abstract::J proteins are a diverse family of co-chaperones that cooperate with heat shock protein 70 (Hsp70) to coordinate protein quality control, especially in response to cellular stress. Current models suggest that individual J proteins might play roles in recruiting Hsp70s to specific functions, such as maintaining cell wa...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25248a
更新日期:2012-11-01 00:00:00
abstract::Intrinsically disordered regions in proteins are known to evolve rapidly while maintaining their function. However, given their lack of structure and sequence conservation, the means through which they stay functional is not clear. Poor sequence conservation also hampers the classification of these regions into functi...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25202c
更新日期:2012-10-30 00:00:00
abstract::The aim of this study was to investigate the cellular lipid metabolism associated with β-amyloid peptide (Aβ)-induced neurotoxicity as well as the neuroprotective effect of (-)-epigallocatechin gallate (EGCG), a major polyphenol in green tea. An ultra-performance liquid chromatography-quadrupole-time-of-flight mass sp...
journal_title:Molecular bioSystems
pub_type: 杂志文章
doi:10.1039/c2mb25126d
更新日期:2012-10-30 00:00:00